Dutogliptin (tartrate)
CAS No. : 890402-81-0
(Synonyms: PHX-1149)
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| Cat. No. : | HY-10286A |
| M.Wt: | 391.18 |
| Formula: | C14H26BN3O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Dutogliptin tartrate (PHX-1149) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus. IC50 & Target: DPP4[1] In Vivo: Dutogliptin exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. Dutogliptin is metabolically stable and does not inhibit or induce the activity of major CYP450s[2].
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