2,4-Dihydroxybenzoic acid
CAS No. : 89-86-1
| Size | Price | Stock |
|---|---|---|
| 100g | $12 | In-stock |
| 500g | $48 | In-stock |
| 1000g | $62 | In-stock |
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| Cat. No. : | HY-W012575 |
| M.Wt: | 154.12 |
| Formula: | C7H6O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
2,4-Dihydroxybenzoic acid is a degradation product of acid cherry anthocyanins during in vitro cell culture and an analogue of coenzyme Q precursor molecules. 2,4-Dihydroxybenzoic acid can improve the related symptoms of kidney diseases caused by ADCK4/Coq6 deficiency[1][2][3].
In Vitro:2,4-Dihydroxybenzoic acid (500 μM) can partially restore the activity of mitochondrial respiratory chain complex II-III, increase the mitochondrial membrane potential, and reduce the ROS level in ADCK4-knockout human podocytes[2].
2,4-Dihydroxybenzoic acid can reverse the impaired podocyte migration rate in human podocytes with transient knockdown of Coq6[3].
In Vivo:2,4-Dihydroxybenzoic acid (25 mM; administered via drinking water; twice a week; from 5 months to 10.5 months of age) can prevent focal segmental glomerulosclerosis (FSGS) and renal fibrosis in podocyte-specific Coq6 knockout mice[3].
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