Chlorothymol

Chlothymol is a potent positive modulator of the GABA_A receptor subunit LGC-37, anticonvulsant, and antibacterial agent. Chlothymol inhibits Pentylenetetrazol-induced c-fos expression. Chlothymol inhibits the growth of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) strains, including LAC, with an MIC of 32 μg/mL. Chlorothymol has protective effects against epileptic seizures in various mouse models^[1][2]. In Vitro:Chlorothymol (25 μM for c-fos detection; 60 min for c-fos detection) suppresses Pentylenetetrazol (PTZ)-induced c-fos expression and reduces seizure-like locomotor behavior in 2-day postfertilization (dpf) and 3-dpf zebrafish embryos/larvae^[1].
Chlorothymol (150 μM; 15 min) reduces PTZ-induced head-bobbing convulsions in seizure-prone Caenorhabditis elegans unc-49(e407) mutant strain^[1].
Chlorothymol inhibits the growth of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) strains including LAC, with a MIC of 32 μg/mL^[2].
In Vivo:Chlorothymol exerts anticonvulsant efficacy in various mouse seizure models, including the 6-Hz 32-mA (ED₅₀ = 18.0 mg/kg, protective index [PI] =8.4), 6-Hz 44-mA (ED₅₀ = 66.2 mg/kg, PI = 2.3)^[1].