Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse
CAS No. : 88898-17-3
(Synonyms: Atrial natriuretic factor (1-28) (rat, mouse))
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| Cat. No. : | HY-P1236 |
| M.Wt: | 3062.41 |
| Formula: | C128H205N45O39S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner. IC50 & Target:Endothelin-1[1] In Vitro: Rat ANP (1-28) and rat BNP-45, which are the respective major circulating forms of ANP and BNP in rats, potently inhibited Ang II-stimulated endothelin-1 secretion in a concentration-dependent manner. Rat ANP (5-25) is less effective that Rat ANP(1-28) with respect to inhibiting immunoreactive (ir)-endothelin-1 secretion and increasing cellular cyclic GMP. Rat ANP (1-28) inhibits the secretion of ir-endothelin-1 in a concentration-dependent manner between 0.01 and 1 μM[1].
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