MET kinase-IN-4
CAS No. : 888719-03-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $195 | In-stock |
| 10mg | $310 | In-stock |
| 25mg | $580 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-18309 |
| M.Wt: | 458.42 |
| Formula: | C25H16F2N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
MET kinase-IN-4 is an orally active Met kinase inhibitor. MET kinase-IN-4 has potent Met kinase inhibitory activity with an IC50 value of 1.9 nM. MET kinase-IN-4 can be used for the research of cancer[1].
IC50 & Target:IC50: 1.9 nM (Met); 4 nM (Flt-3); 27 nM (VEGFR-2)[1]
In Vitro:MET kinase-IN-4 (Compound 2) has potent Met kinase inhibitory activity with an IC50 value of 1.9 nM[1].
MET kinase-IN-4 inhibits Flt-3 and VEGFR-2 kinases with IC50 values of 4 and 27 nM, respectively[1].
MET kinase-IN-4 (3 μM) shows good metabolic stability in both human and mouse liver microsomes[1].
In Vivo:MET kinase-IN-4 (Compound 2) (i.v., p.o.; 5, 10 mg/kg) possesses a favorable pharmacokinetic profile in mice[1].
MET kinase-IN-4 (p.o.; 6.25, 12.5, 25 and 50 mg/kg; once a day) demonstrates significant in vivo antitumor activity in the GTL-16 human gastric carcinoma xenograft model[1].
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