GF 15


CAS No. : 888042-13-5

888042-13-5
Price and Availability of CAS No. : 888042-13-5
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Cat. No. : HY-12797
M.Wt: 428.86
Formula: C23H21ClO6
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 888042-13-5 :

GF 15 is a potent inhibitor of centrosomal clustering in tumor cells. IC50 & Target: Centrosomal clustering[1] In Vitro: GF 15 leads to multipolar mitosis induction with an EC50 of 900 nM. GF 15 exhibits potent cytotoxicity in a concentration-dependent manner against a broad spectrum of tumor cell types including colon, cervix, glioblastoma, pancreas, leukemia, and myeloma-derived cell lines with IC50s of 1-5 μM[1]. In Vivo: Treatment of mouse xenograft models of human colon cancer and multiple myeloma with GF 15 results in tumor growth inhibition and significantly prolonged survival[1].

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