Eckol

Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC₅₀s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects^[1][2][3][4]. In Vitro: Pretreatment with Eckol (25-100 μg/mL; 2 h) significantly reduces β-hexosaminidase release in IgE/BSA-stimulated BMCMC in a dose-dependent manner^[3].
Eckol (25-100 μg/mL; 1 h) inhibits the production of Th2-type cytokines, such as IL-4, IL-5, and IL-13 as well as proinflammatory cytokines, such as IL-6^[3].
Eckol (25-100 μg/mL) attenuates cytokine mRNA levels such as IL-1β, IL-4, IL-5, IL-6, IL-13, IFN-γ, and TNF-α in IgE/BSA-stimulated BMCMC^[3].
Eckol (25-100 μg/mL; 1 h) inhibits NF-κB activation in IgE/BSA-stimulated BMCMC^[3].
Eckol showes a moderate IC₅₀ value (89.5 µM) against the influenza A/Bervig-Mission/1/18 (H1N1) virus^[4]. In Vivo: Foliar application of Eckol (1 μM) significantly enhanced shoot and root length, shoot and root fresh and dry weight, leaf area and leaf number^[2].
Eckol (50 or 100 μg/mouse; intradermal; once) reduces allergic inflammatory responses in the passive cutaneous anaphylaxis (PCA)-induced mice^[3].