MK-0674


CAS No. : 887781-62-6

887781-62-6
Price and Availability of CAS No. : 887781-62-6
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Cat. No. : HY-10290
M.Wt: 527.50
Formula: C26H27F6N3O2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 887781-62-6 :

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S[1]. IC50 & Target: IC50: 0.4 nM (Cathepsin K)[1] In Vitro: MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM[1].

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