PF-3052334
CAS No. : 887702-61-6
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| Cat. No. : | HY-11088 |
| M.Wt: | 533.57 |
| Formula: | C28H33FN3NaO5 |
| Purity: | >98 % |
| Solubility: |
PF-3052334 is an orally active, hepatically selective HMG-CoA reductase inhibitor with an IC50 of 1.9 nM. PF-3052334 inhibits cholesterol synthesis, with IC50 values of 0.9 and 730 nM in hepatocytes and muscle cells, respectively. PF-3052334 can be used to study hypercholesterolemia[1].
In Vivo:PF-3052334 (10 mg/kg, p.o., single dose) PF-3052334 significantly inhibits cholesterol synthesis at both 2-4 h and 4-6 h in hamsters[1].
PF-3052334 (20 mg/kg, p.o., once daily for 7 days) causes low density lipoprotein (LDL) reduction in guinea pigs with an ED50 of 3.6 mg/kg[1].
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