(S)-Mapracorat
CAS No. : 887375-15-7
(Synonyms: (S)-ZK-245186; (S)-BOL-303242X)
| Size | Price | Stock |
|---|---|---|
| 1mg | $260 | In-stock |
| 5mg | $650 | In-stock |
| 10mg | $950 | In-stock |
| 25mg | $1800 | In-stock |
| 50mg | $2800 | In-stock |
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| Cat. No. : | HY-14864A |
| M.Wt: | 462.48 |
| Formula: | C25H26F4N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50.61 mg/mL (ultrasonic;warming) |
(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist. In Vitro: (S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM. In Vivo: Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.
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