Pyributicarb
CAS No. : 88678-67-5
(Synonyms: TSH-888)
| Size | Price | Stock |
|---|---|---|
| 25mg | $52 | In-stock |
| 50mg | $78 | In-stock |
| 100mg | $110 | In-stock |
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| Cat. No. : | HY-111202 |
| M.Wt: | 330.44 |
| Formula: | C18H22N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). IC50 & Target: CYP3A4[1], hPXR[2] In Vitro: Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells[1]. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF)[2]. In Vivo: Pyributicarb causes enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus[1].
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