Apogossypolone
CAS No. : 886578-07-0
(Synonyms: ApoG2)
| Size | Price | Stock |
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| 5mg | $1050 | In-stock |
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| Cat. No. : | HY-19551 |
| M.Wt: | 490.50 |
| Formula: | C28H26O8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis[1] and autophagy[2]. Apogossypolone also has antifungal activity[3].
In Vitro: Apogossypolone (ApoG2) shows improved stability under stressed conditions[1].
Apogossypolone (0-1 μM, 72 or 96 h) inhibits WSU-DLCL2 cells growth in a dose-dependent manner[1].
Apogossypolone (0-5 μM, 24 or 48 h) interferes with the formation of heterodimers between anti-apoptotic and pro-apoptotic Bcl-2 family members, and leads to cleavage of caspase-3, caspase-9 and PARP[1].
Apogossypolone (0-8 μM, 0-72 h) induces apoptotic WSU-DLCL2 cell death in a time- and dose-dependent manner[1].
Apogossypolone (0-10 μM, 0-24 h) induces autophagy and promotes ROS generation in HCC cells[2].
In Vivo: Apogossypolone (ApoG2) (120 mg/kg; i.v. or p.o.; once a day for 5 days) effectively inhibits growth of diffuse large cell lymphoma cells without toxicity[1].
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