FX-06
CAS No. : 88650-17-3
(Synonyms: Fibrin-derived peptide Bβ15-42)
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $128 | In-stock |
| 10mg | $200 | In-stock |
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| Cat. No. : | HY-106275 |
| M.Wt: | 3039.41 |
| Formula: | C133H216N44O38 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS)[1][2][4].
In Vitro:FX-06 (50 μM, 3 days) inhibits the production of D2HG in HEK-293T cells transfected with IDH1 R132H[2].
In Vivo:FX06 (2.4 mg/kg, i.v. bolus) shows significantly improved pulmonary and circulatory function in a pig model of hemorrhagic shock and reperfusion[3].
FX06 (2.4 mg/kg, i.p., twice daily) improves survival and reduces capillary leak in mice with Dengue-induced shock[4].
FX06 (3.6 mg/kg, i.v.) protects mice from Ischemia/reperfusion (I/R)-induced kidney injury by aiding in epithelial cell proliferation and tissue repair[5].
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