c-Fms-IN-3
CAS No. : 885704-21-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $230 | In-stock |
| 10mg | $350 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-13075 |
| M.Wt: | 406.52 |
| Formula: | C23H30N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
c-Fms-IN-3 is an orally active c-Fms (CSF1R) kinase inhibitor (IC50 = 0. 8 nM). c-Fms-IN-3 inhibits CSF1R kinase activity and reduces macrophage populations. c-Fms-IN-3 reduces bone erosion, pannus invasion, cartilage damage, and inflammation in collagen (HY-NP003)-induced arthritis mouse model. c-Fms-IN-3 is useful for arthritis research[1][2].
IC50 & Target:c-Fms.
In Vitro:c-Fms-IN-3 (Compound 8) inhibits the receptor tyrosine kinases Kit, Axl, TrkA, and Flt-3 and IRK-β, with IC50s of 0.0035, 0.0064, 0.011, 0.018, 0.083 μM[1].
In Vivo:c-Fms-IN-3(Compound 8) (5-30 mg/kg, p.o., twice-daily, 14 days) reduces bone erosion, pannus invasion, cartilage damage and inflammation in a Collagen (HY-NP003)-induced model of arthritis in mice[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- c-Fms-IN-3
- Cat. No.:
- HY-13075
- Quantity:
Your information is safe with us.