HJC0350
CAS No. : 885434-70-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $480 | In-stock |
| 200mg | $820 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-15702 |
| M.Wt: | 277.38 |
| Formula: | C15H19NO2S |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM. IC50 & Target: IC50: 0.3 µM (EPAC2)[1] In Vitro: HJC0350 has an apparent IC50 value of 0.3 µM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 µM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 µM HJC0350 fully blocks the 007-AM induced decrease of FRET[1].
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