MK-8745
CAS No. : 885325-71-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $45 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $120 | In-stock |
| 50mg | $185 | In-stock |
| 100mg | $300 | In-stock |
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| Cat. No. : | HY-13819 |
| M.Wt: | 431.91 |
| Formula: | C20H19ClFN5OS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
MK-8745 is an aurora A kinase inhibitor with an IC50 of 0.6 nM. IC50 & Target: IC50: 0.6 nM (Aurora A)[1] In Vitro: MK-8745 induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK-8745 results in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression[1]. 1 μM of MK-8745 exposure for 24 h induces cell cycle arrest in all NHL cells, with variable degrees of G2/M arrest. Z138C cells are highly sensitive to MK-8745 (1 μ M) treatment and induces an approximate 5.5-fold increase in the G2/M phase cell population by 96 h. MK-8745 treatment inhibits phosphorylation of Aurora-A in Granta 519 and Z138C cells, while Akata and JVM2 has no effect. MK-8745 specifically inhibits Aurora-A specific function. MK-8745 treatment leads to apoptotic cell death[2].
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