Dichotomitin
CAS No. : 88509-91-5
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| 10mg | $220 | In-stock |
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| Cat. No. : | HY-N2120 |
| M.Wt: | 358.30 |
| Formula: | C18H14O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 11.11 mg/mL (ultrasonic;warming;heat to 60°C) |
Dichotomitin is an isoflavonoid compound isolated from the rhizomes of Belamcanda chinensis. Dichotomitin exhibits antioxidant activity, alleviates oxidative stress, reduces intracellular reactive oxygen species (ROS) levels, and upregulates the expression of SOD1, SOD2 and CAT. Dichotomitin increases ALP activity while upregulating the expression of RUNX2, OPN and OCN. Dichotomitin has antitussive activity and helps improve symptoms of upper respiratory tract infections[1][2][3][4].
In Vitro:Dichotomitin (0.5-2.0 µM; 24-96 h) promotes human bone marrow stromal HS-5 cell proliferation at 1.0 and 1.5 µM, and inhibits proliferation at 2.0 µM when incubated for 24, 48, 72, or 96 h[1].
Dichotomitin (0.5-2.0 µM; 7 days) enhances ALP activity and staining, markers of early osteogenic differentiation, in human bone marrow stromal HS-5 cells at 0.5, 1.0, and 1.5 µM after 7 days of osteogenic induction[1].
Dichotomitin (0.5-2.0 µM; 21 days) promotes mineralized nodule formation, a marker of late osteogenic differentiation, in human bone marrow stromal HS-5 cells at 0.5, 1.0, and 1.5 µM after 21 days of osteogenic induction[1].
Dichotomitin (0.5-2.0 µM) significantly upregulates COL1A1, RUNX2, OSX, OPN, and OCN gene expression in human bone marrow stromal HS-5 cells at 1.0 and 1.5 µM during osteogenic differentiation[1].
Dichotomitin restores ALP activity and mineralized nodule formation in hydrogen peroxide-impaired osteogenic differentiation of human bone marrow stromal HS-5 cells[1].
Dichotomitin (10 μM; 1 h) produces four metabolites, with M6 and M8 as the most abundant, and yields comparable metabolic profiles across rat, monkey, and human liver microsomes with greater formation of M6 and M8 in rat and monkey than in human[2].
Dichotomitin (10 μM; 1 h) shows that CYP1A2, 2C19, and 2D6 drive M6 production, while only CYP1A2 catalyzes M8 production in human recombinant CYP enzymes[2].
Dichotomitin reduces intracellular ROS levels in hydrogen peroxide-induced oxidative stress models of human bone marrow stromal HS-5 cells[1].
In Vivo:Dichotomitin (5 mg/kg; i.p.; twice weekly; 3 months) improves trabecular bone microstructure, increases serum osteogenic marker levels, and inhibits osteoclastic bone resorption to alleviate osteoporosis in OVX rats[1].
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