GSM-1
CAS No. : 884600-68-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $550 | In-stock |
| 10mg | $950 | In-stock |
| 25mg | $1950 | In-stock |
| 50mg | $3250 | In-stock |
| 100mg | $5350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-119165 |
| M.Wt: | 481.98 |
| Formula: | C26H31ClF3NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1)[1][2].
In Vitro: GSM-1 increases the levels of Aβ38 produced from WT APP. GSM-1 potently loweres the levels of Aβ42 of WT APP and all the Phe mutants by ∼70–80%, even for the V44F mutant, which produced only extremely small amounts of Aβ42[1].
GSM-1 directly binds to the N-terminal fragment of PS1[2].
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