Clodronate (disodium tetrahydrate)
CAS No. : 88416-50-6
(Synonyms: Disodium clodronate (tetrahydrate))
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| 100mg | $45 | In-stock |
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| Cat. No. : | HY-107794 |
| M.Wt: | 360.92 |
| Formula: | CH10Cl2Na2O10P2 |
| Purity: | >98 % |
| Solubility: | H2O : 125 mg/mL (ultrasonic) |
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2].
IC50 & Target:vesicular ATP release[1]
In Vitro: Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission [1].
Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence [1].
Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis[2].
In Vivo: Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition[1].
Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition [1].
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