Boc-NH-PEG6-CH2CH2COOH
CAS No. : 882847-13-4
| Size | Price | Stock |
|---|---|---|
| 1g | $45 | In-stock |
| 5g | $175 | In-stock |
| 10g | $349 | In-stock |
| 25g | $871 | In-stock |
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| 100 g | Get quote | |
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| Cat. No. : | HY-W040244 |
| M.Wt: | 453.52 |
| Formula: | C20H39NO10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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