AI-3
CAS No. : 882288-28-0
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| Cat. No. : | HY-107736 |
| M.Wt: | 292.80 |
| Formula: | C11H13ClO3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases[1].
IC50 & Target:ARE[1]
In Vitro:AI-3 (0.1, 0.3, 1, 3.2, 10, 32 µM; 12, 24 h) increases the NQO1 at the transcript levels and protein expression levels in a dose-dependent manner in IMR-32 cells[1].
AI-3 (10 µM; 2-24 h) induces GSH synthesis starting from 4 h up to 24 h[1].
AI-3 requires Nrf2 and PI3K for its bioactivities in IMR-32 cells[1].
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