SGM8
CAS No. : 882268-09-9
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| Cat. No. : | HY-21302 |
| M.Wt: | 253.38 |
| Formula: | C12H15NOS2 |
| Purity: | >98 % |
| Solubility: |
SGM8 is a selective HCMV UL44 inhibitor, with an IC50 of 4.5 μM for the interaction between HCMV UL44 and full-length HCMV UL54. SGM8 selectively inhibits UL44-dependent long-strand DNA synthesis, while exerting weak inhibitory effects on UL54-only dependent short-strand DNA synthesis. SGM8 can be used in studies related to cytomegalovirus infection[1].
In Vitro:SGM8 (0.1-100 μM; 10-60 min) time-dependently inhibits the interaction of HCMV UL44 with the UL54-derived P54 peptide, with an IC50 of 2 μM following 20 min or longer of pre-incubation[1].
SGM8 (0.1-100 μM) inhibits the interaction of HCMV UL44 with full-length HCMV UL54 with an IC50 of 4.5 μM[1].
SGM8 (0.1-100 μM) selectively inhibits UL44-dependent long-chain DNA synthesis by HCMV UL54 with an IC50 of 3.2 μM, while showing minimal inhibition of short-chain DNA synthesis by UL54 alone (IC50 > 100 μM)[1].
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