Notopterol
CAS No. : 88206-46-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $46 | In-stock |
| 25mg | $83 | In-stock |
| 50mg | $124 | In-stock |
| 100mg | $187 | In-stock |
| 250mg | $337 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-N0564 |
| M.Wt: | 354.40 |
| Formula: | C21H22O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML)[1].
In Vitro: notopterol (5, 10, 20, 40, 60 μM; for 48 hours) promotes cell apoptosis in a dose-dependent manner[1].
notopterol (10, 20, 40, 60 and 80 μM; 24-120 hours) inhibits the proliferation of HL-60 cells in a concentration-dependent manner[1].
Notopterol (5, 10, 20 and 40 μM; for 48 hours) induces G0/G1 phase arrest associated with cell-cycle proteins in HL-60 cells[1].
Notopterol (5, 10, 20 and 40 μM; for 48 hours) increases the expression of Bax and decreased the expression of Bcl-2 and Mcl-1 in HL-60 cells after 48-hr treatment. Moreover, Notopterol also promotes the cleavage of caspase 9, caspase 3 and PARP[1].
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