Diphenyl disulfide
CAS No. : 882-33-7
(Synonyms: Phenyl disulfide)
| Size | Price | Stock |
|---|---|---|
| 5g | $11 | In-stock |
| 10g | $16 | In-stock |
| 25g | $18 | In-stock |
| 100g | $52 | In-stock |
| 500g | $151 | In-stock |
| 1000g | $198 | In-stock |
| > 2 kg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-Y1177 |
| M.Wt: | 218.35 |
| Formula: | C12H10S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Diphenyl disulfide (Phenyl disulfide) is an organic disulfide compound. Diphenyl disulfide inhibits the PI3K/AKT/mTOR pathway, and induces ferroptosis (ferroptosis), apoptosis (apoptosis) and autophagy (autophagy) in cancer cells. Diphenyl disulfide downregulates GPX4 expression, inhibits NRF2 phosphorylation, induces lipid peroxidation, promotes xCT ubiquitination, induces proteolytic cleavage of p21 Bax into p18 Bax, and suppresses cell proliferation and viability. Diphenyl disulfide can be used in research related to melanoma and breast cancer[1][2][3].
In Vitro:Diphenyl disulfide (0-30 μM; 24-48 h) inhibits the viability of B16F10 and A375 melanoma cells[1].
Diphenyl disulfide (0-30 μM; 24-48 h) induces non-apoptotic cell death (ferroptosis) in mouse B16F10 melanoma cells at 24 h by downregulating GPX4 expression, enhancing lipid peroxidation levels and promoting xCT ubiquitination, and induces apoptosis at 48 h, with reduced phosphorylated NRF2 levels associated with late-stage apoptosis[1].
Diphenyl disulfide (0-30 μM; 24-48 h) induces autophagy in mouse B16F10 melanoma cells in vitro in a dose-dependent manner[1].
Diphenyl disulfide (0-30 μM; 24 h) reduces the protein levels of phosphorylated AKT1/2/3 and mTOR in a dose-dependent manner, and inhibits the PI3K/AKT/mTOR signaling pathway in B16F10 melanoma cells[1].
Diphenyl disulfide (0-30 μM; 24-48 h) reduces the viability of MDA-MB-231 and MCF-7 breast cancer cells in a dose-dependent manner, with IC50 values of 24.14, 25.57, 19.45, and 16.89 μM after 24 h and 48 h of treatment, respectively[2].
Diphenyl disulfide (0-30 μM; 24-48 h) induces apoptosis in MDA-MB-231 breast cancer cells in a dose-dependent manner. After treatment with 30 μM, the proportions of annexin V-positive cells reach 31.1% and 63.8% at 24 h and 48 h, respectively[2].
Diphenyl disulfide (0-30 μM; 24-48 h) induces cleavage of p21 Bax into pro-apoptotic p18 Bax in MDA-MB-231 and MCF-7 breast cancer cells[2].
Diphenyl disulfide (10-30 μM; 24-48 h) dose-dependently upregulates the level of LC3B-II, a marker of autophagosome formation, in MDA-MB-231 and MCF-7 breast cancer cells[2].
Diphenyl disulfide (10-30 μM; 24 h) dose-dependently increases the formation of acidic vesicular organelles, a marker of autophagy, in MDA-MB-231 and MCF-7 breast cancer cells[2].
Diphenyl disulfide (10-30 μM; 24-48 h) increases the level of lysosomal aggregation in MDA-MB-231 breast cancer cells[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Diphenyl disulfide
- Cat. No.:
- HY-Y1177
- Quantity:
Your information is safe with us.