iMDK
CAS No. : 881970-80-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $497 | In-stock |
| 50mg | $700 | In-stock |
| 100mg | $970 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110171 |
| M.Wt: | 376.40 |
| Formula: | C21H13FN2O2S |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic);DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C) |
iMDK is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice[1]. In Vitro: iMDK (50–500 nM) suppressed AKT phosphorylation in a dose-dependent manner in H441 lung adenocarcinoma cells after treatment for 72 h. In contrast, iMDK robustly increases p-ERK[1]. In Vivo: The combination treatment of iMDK ( (9 mg/kg/day; intraperitoneally injected with 100 μl) and PD0325901 (5 mg/kg; orally administered) effectively reduced lung tumor growth in a xenograft mouse model[1].
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