Amlodipine
CAS No. : 88150-42-9
| Size | Price | Stock |
|---|---|---|
| 500mg | $55 | In-stock |
| 1g | $92 | In-stock |
| 5g | $290 | In-stock |
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| Cat. No. : | HY-B0317 |
| M.Wt: | 408.88 |
| Formula: | C20H25ClN2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 31.25 mg/mL (ultrasonic) |
Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].
IC50 & Target:L-type calcium channel[1]
In Vitro: Amlodipine (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively[3].
Amlodipine (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells[3].
Amlodipine (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells[3].
In Vivo: Amlodipine (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice[4].
Amlodipine (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3].
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