KPT-6566
CAS No. : 881487-77-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $360 | In-stock |
| 10mg | $468 | In-stock |
| 25mg | $655 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123847 |
| M.Wt: | 443.54 |
| Formula: | C22H21NO5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 19.23 mg/mL (ultrasonic) |
KPT-6566 is a selective and covalent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 value of 640?nM and a Ki value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer[1].
IC50 & Target: IC50: 640?nM (PIN1 PPIase)[1]
Ki: 625.2 nM (PIN1 PPIase)[1]
In Vitro: KPT-6566 (1-5 μM; 0-8 d) inhibits WT fibroblasts proliferation[1].
KPT-6566 (0-10 μM; 48 h) inhibits normal breast epithelial cells and cancer cells viability via a PIN1-dependent manner[1].
KPT-6566 (0-10 μM; 48 h) affects hyperphosphorylated pRB level, Cyclin D1 and PIN1 concentration[1].
KPT-6566 (2.5-5 μM; 48 h) inhibits the mut-p53, NOTCH1 and NRF2 pathways[1].
KPT-6566 (0-5 μM; 48 h) induces DNA damage via a PIN1-dependent way[1].
In Vivo: KPT-6566 (5 mg/kg; i.p. once a day for 26 days) shows no toxicity to mice[1].
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