Serdemetan
CAS No. : 881202-45-5
(Synonyms: JNJ-26854165)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $265 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12025 |
| M.Wt: | 328.41 |
| Formula: | C21H20N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Serdemetan (JNJ-26854165) is a potent anticancer agent with radiosensitizing activity. Serdemetan exhibits antiproliferative activity in various p53 wild-type tumor cells. Serdemetan also antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes[1][2][3].
In Vitro:Serdemetan (0.5-50 μM; 48-72 h) inhibits cell proliferation of H460, A549, p53-WT HCT116, p53-null HCT116 and HMEC-1 cells in a dose-dependent manner[1].
Serdemetan (0.25-5 μM; 48 h) triggers cell arrests in G2/M phase of A549 cells and H460 cells[1].
Serdemetan (0.5-10 μM; 48 h) increases expression of p53 and p21 in H460, A549 and p53-WT HCT116 cells[1].
Serdemetan (0.25-10 μM; 12-14 d) affects clonogenic survival in H460, A549 p53-WT HCT116 and p53-null HCT116 cells[1].
Serdemetan (0.25-5 μM; 12-14 d) increases radiation-induced clonogenic inhibition[1].
Serdemetan (5-20 μM; 4-24 h) inhibits neovessels formation and delays scratch wound repair of HMEC-1 cells[1].
In Vivo:Serdemetan (50 mg/kg) enhances radiation-induced growth delays in H460 and A549 xenograft tumors[1].
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