Foxy-5
CAS No. : 881188-51-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $350 | In-stock |
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| Cat. No. : | HY-P1416 |
| M.Wt: | 694.77 |
| Formula: | C26H42N6O12S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2][3].
IC50 & Target:WNT5A[2]
In Vitro:Foxy-5 (100 μM, 24 h) inhibits the invasion of tumor cells in DU145 cells[3].
In Vivo:Foxy-5 (2 mg/kg intraperitoneally injected 9 times a day for 7-23 days) reduces the number of colon cancer stem cells in a mouse model of human colon cancer xenotransplantation[2].
Foxy-5 (2 mg/kg, intraperitoneal injection, once a day, for 3-9 weeks) significantly reduces the early metastasis and spread of WNT5A low DU145 prostate cancer cells in a mouse model of prostate cancer xenotransplantation[3].
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