Naloxonazine (dihydrochloride)
CAS No. : 880759-65-9
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| 10mg | $320 | In-stock |
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| Cat. No. : | HY-101011 |
| M.Wt: | 723.69 |
| Formula: | C38H44Cl2N4O6 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 25 mg/mL |
Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity[1][2][3].
In Vitro: Naloxonazine is relatively stable in solution[2].
Naloxonazine (72 h) is active against the intracellular amastigote stage of Leishmania donovani with a half maximal inhibitory concentration (GI50) of 3.45 μM[3].
Naloxonazine (10 μM; 0-72 h) is active at early stages of Leishmania donovani infection[3].
Naloxonazine affects acidic compartments of the host cell which in turn limit L. donovani intracellular growth[3].
In Vivo: Naloxonazine (20 mg/kg; i.p.; once) attenuates the increment of locomotor activity induced by acute methamphetamine in mice[1]
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