Pilsicainide (hydrochloride)
CAS No. : 88069-49-2
(Synonyms: SUN-1165; Pilzicainide(hydrochloride))
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| Cat. No. : | HY-101245 |
| M.Wt: | 308.85 |
| Formula: | C17H25ClN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent[1][2]. In Vitro: Pilsicainide hydrochloride (SUN-1165) (10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 ± 22.9 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1]. In Vivo: Pilsicainide hydrochloride (SUN-1165) (2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current[1].
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