Naxagolide
CAS No. : 88058-88-2
(Synonyms: (+)-PHNO; Dopazinol)
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $650 | In-stock |
| 50mg | $1050 | In-stock |
| 100mg | $1700 | In-stock |
| 500mg | $3400 | In-stock |
| 1g | $4760 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-108237 |
| M.Wt: | 247.33 |
| Formula: | C15H21NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD)[1][2].
In Vitro:In vitro, Naxagolide ((+)-PHNO) inhibits binding of [3H]apomorphine (IC50 = 23 nM) or [3H]spiperone (IC50 = 55 nM) to rat striatal membranes[1].
In Vivo:In mice, Naxagolide ((+)-PHNO) produces hypothermia (13 μg/kg i.p.) and postural asymmetry in the unilaterally caudectomized animal (4 μg/kg i.p.)[1].
In the rat, Naxagolide ((+)-PHNO) produces stereotypy (10 μg/kg i.p.) and contralateral turning in 6-hydroxydopamine-lesioned animals (5 μg/kg i.p.) that lasted 1 to 3 hr[1].
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