Phthalazinone pyrazole
CAS No. : 880487-62-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $52 | In-stock |
| 10mg | $84 | In-stock |
| 25mg | $168 | In-stock |
| 50mg | $253 | In-stock |
| 100mg | $380 | In-stock |
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| Cat. No. : | HY-12564 |
| M.Wt: | 317.34 |
| Formula: | C18H15N5O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 11.11 mg/mL |
Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells[1][2]. In Vitro: Phthalazinone pyrazole (1 and 10 μM; 30 hours) enhances the proliferative capacity of HLCs[2]. Phthalazinone pyrazole (1, 10, and 100 μM; 5 days) enhances hepatic morphological changes in differentiated HLCs without cytotoxicity[2]. Phthalazinone pyrazole (1 and 10 μM; 5 and 17 days) suppresses the EMT and induced maturation of HLCs through the inhibition of the AKT signaling pathway by the off target effect with concomitant upregulation of HNF4α rather than direct inhibition of Aurora-A. The result is confirmed by western blot and qPCR[2].
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