2,5-Di-tert-butylhydroquinone
CAS No. : 88-58-4
| Size | Price | Stock |
|---|---|---|
| 25g | $11 | In-stock |
| 500g | $31 | In-stock |
| 1000g | $53 | In-stock |
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| Cat. No. : | HY-W012399 |
| M.Wt: | 222.33 |
| Formula: | C14H22O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
2,5-Di-tert-butylhydroquinone (BHQ) (Compound 2), an indirect food additive, is a Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor with an IC50 of 400 nM. 2,5-Di-tert-butylhydroquinone disrupts the gating function of the residue Glu309 which prevents Ca2+ from reaching their binding site. 2,5-Di-tert-butylhydroquinone regulates the activity of 5-lipoxygenase and COX-2 (IC50: 1.8 and 14.1 μM for 5-LO and COX-2, respectively)[1][2]. In Vitro:DTBHQ influences arachidonic acid (AA) metabolism in biologically relevant concentrations in vitro[1].
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