Vismodegib
CAS No. : 879085-55-9
(Synonyms: GDC-0449)
| Size | Price | Stock |
|---|---|---|
| 5mg | $28 | In-stock |
| 10mg | $40 | In-stock |
| 25mg | $66 | In-stock |
| 50mg | $86 | In-stock |
| 100mg | $111 | In-stock |
| 200mg | $145 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-10440 |
| M.Wt: | 421.30 |
| Formula: | C19H14Cl2N2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);Ethanol : 3.33 mg/mL (ultrasonic;warming;heat to 60°C) |
Vismodegib (GDC-0449) is a BBB-permeable and orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively[1][2]. IC50 & Target:IC50: 3 nM (hedgehog), 3.0 μM (P-gp), 1.4 μM (ABCG2)[1][2] In Vitro:Vismodegib (HhAntag691) is an ABCG2 inhibitor and can increase the effective intracellular concentration of NSC 279836, another ABCG2 substrate, through blocking its export in HEK293 cells. Vismodegib (HhAntag691, 10 μM), resensitizes MDCKII/Pgp cells and MDCKII/MRP1 cells to NSC757 treatment[2]. Vismodegib (25 μM or 50 μM) concentration-dependently inhibits HCC and H1339 cells[3]. In Vivo:Vismodegib (0.3 to 75 mg/kg, p.o.) is highly efficacious in medulloblastoma allograft tumors. Vismodegib (> 46 mg/kg, p.o.) causes growth delay in patient-derived colorectal xenografts[4].
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