WRW4
CAS No. : 878557-55-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1125 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-P1119 |
| M.Wt: | 1104.27 |
| Formula: | C61H65N15O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic) |
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1]. In Vitro: WRW4 inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages. WRW4 specifically blocks ERK phosphorylation downstream of FPRL1 by WKYMVm[1].
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