Glucagon-like peptide 1 (1-37), human
CAS No. : 87805-34-3
(Synonyms: GLP-1 (1-37) human)
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| Cat. No. : | HY-P1145 |
| M.Wt: | 4169.48 |
| Formula: | C186H275N51O59 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor. IC50 & Target:GLP-1 receptor[1] In Vitro: Glucagon-like peptide-1 (GLP-1) is produced by the posttranslational processing of proglucagon and acts as a regulator of various homeostatic events. GLP-1(1-37) is more stable than GLP-1(7-37), with 94.7% of the initial amount of peptide left after a 4h exposure to mouse serum. GLP-1(1-37) is confirmed to be a highly potent agonist of the GLP-1 receptor (GLP-1R) by measuring the expression of the luciferase reporter gene expression in transiently transfected human embryonic kidney (HEK293) cells[1]. In Vivo: GLP-1(1–37) decreased glycemic excursion in a dose-dependent. The administration of GLP-1(1–37) or GLP-1(7–37) markedly decrease blood glucose levels at 15 min and 30 min compared with the control group[1].
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