(E)-[6]-Dehydroparadol
CAS No. : 878006-06-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $105 | In-stock |
| 10mg | $147 | In-stock |
| 25mg | $265 | In-stock |
| 50mg | $370 | In-stock |
| 100mg | $520 | In-stock |
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| Cat. No. : | HY-77293 |
| M.Wt: | 276.37 |
| Formula: | C17H24O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells[1][2].
IC50 & Target: Nrf2[2]
In Vitro: (E)-[6]-Dehydroparadol (M15) (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC50s of 43.02 and 41.59 µM, respectively[1].
(E)-[6]-Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells[1].
In Vivo: (E)-[6]-Dehydroparadol (compound 19) (5 µM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos[2].
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