Eupalinolide B
CAS No. : 877822-41-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $195 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $465 | In-stock |
| 100mg | $670 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0753 |
| M.Wt: | 462.49 |
| Formula: | C24H30O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Eupalinolide B is a germ sesquiterpene. Eupalinolide B can be isolated from Eupatorium lindleyanum.
Eupalinolide B induces Apoptosis, elevates ROS, promotes Autophagy. regulates GSK-3β/β-catenin, targets UBE2D3 and TAK1, activates ROS-ER-JNK, inhibits NF-κB and MAPKs. Eupalinolide B has anticancer activity against pancreatic cancer and liver cancer. Eupalinolide B relieves rheumatoid arthritis, acute lung injury, periodontitis, depression[1][2][3][4][5][6][7].
In Vitro:Eupalinolide B (0-10 μM; 24 h) inhibits the viability of pancreatic cancer cell lines MiaPaCa-2, PANC-1, and PL-45 more significantly than normal pancreatic cells HPNE[1].
Eupalinolide B (0-32 μM; 48 h) reduces the viability of RA-FLS in a concentration-dependent manner[2].
Eupalinolide B (0-10 μM; 1 h) inhibits the production of NO in LPS-stimulated RAW264.7 cells in a dose-dependent manner, with an IC50 value of 2.24 μM[3].
Eupalinolide B (6-24 μM; 24-72 h) significantly inhibits the growth of human hepatocarcinoma cell lines SMMC-7721 and HCCLM3[4].
EB (6-24 μM; 24 h) inhibits the migration of human hepatic carcinoma cells (SMMC-7721 and HCCLM3) via activating ROS-ER-JNK signaling pathway[4].
Eupalinolide B (0.125-1 μM; 48 h) promotes Corticosterone (HY-B1618)-induced PC12 cell proliferation and improve cell viability[6].
In Vivo:Eupalinolide B (20-40 mg/kg; i.p.; daily; 4 weeks) shows antitumor effects in a xenograft mouse model of pancreatic cancer[1].
Eupalinolide B (8-16 mg/kg; i.p.; daily; 2 weeks) alleviates rheumatoid arthritis in adjuvant-induced arthritis (AIA) rats[2].
Eupalinolide B (5-20 mg/kg; i.p.; administered 2 h before and 6 h, 18 h after LPS treatment) significantly alleviates LPS-induced acute lung injury in mice, manifested as a reduction in lung injury score, myeloperoxidase activity[3].
Eupalinolide B (25-50 mg/kg; i.p.; every 2 days; 3 weeks) significantly inhibits the growth of tumors formed by human hepatocarcinoma cell lines SMMC-7721 or HCCLM3 in nude mice, reducing tumor volume and weight[4].
Eupalinolide B (30 mg/kg; i.p.; daily; 14 days) can effectively improve periodontal inflammatory damage in a mouse periodontitis model and inhibit alveolar bone resorption[5].
Eupalinolide B (5-20 mg/kg; i.p.; once a day; 22 to 35 days after CUMS exposure) can improve the depressive-like behavior of CUMS rats, reduce hippocampal tissue pathological damage, and promote hippocampal neurogenesis[6].
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