ML221
CAS No. : 877636-42-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $290 | In-stock |
| 100mg | $470 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-103254 |
| M.Wt: | 385.35 |
| Formula: | C17H11N3O6S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL |
ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays. IC50 & Target:IC50: 1.75 μM (APJ, cell-based)[1] In Vitro:ML221 is a potent apelin/APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays. ML221 is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor (IC50, >79 μM) in cells. ML221 displays limited cross reactivity against a range of GPCRs except the κ-opioid and benzodiazepinone receptors (<50/<70%I at 10 μM)[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- ML221
- Cat. No.:
- HY-103254
- Quantity:
Your information is safe with us.