Crizotinib (acetate)
CAS No. : 877399-53-6
(Synonyms: PF-02341066 (acetate))
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| Cat. No. : | HY-50878B |
| M.Wt: | 510.39 |
| Formula: | C23H26Cl2FN5O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Crizotinib (PF-02341066) acetate is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib acetate inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib acetate is also a ROS1 inhibitor. Crizotinib acetate has effective tumor growth inhibition[1][2][3].
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