RF9
CAS No. : 876310-60-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $108 | In-stock |
| 5mg | $228 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-107382 |
| M.Wt: | 482.62 |
| Formula: | C26H38N6O3 |
| Purity: | >98 % |
| Solubility: | H2O : 16.67 mg/mL (ultrasonic);DMSO : 125 mg/mL (ultrasonic) |
RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].
IC50 & Target: Ki: 58±5 nM (hNPFF1R), 75±9 nM (hNPFF2R)[1]
In Vitro: RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells[2].
In Vivo: RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[1].
RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1].
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