Selepressin
CAS No. : 876296-47-8
(Synonyms: FE 202158)
| Size | Price | Stock |
|---|---|---|
| 1mg | $320 | In-stock |
| 5mg | $750 | In-stock |
| 10mg | $1200 | In-stock |
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| Cat. No. : | HY-105239 |
| M.Wt: | 1048.28 |
| Formula: | C46H73N13O11S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4].
In Vitro:Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction[3].
Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs[3].
Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs[3].
In Vivo:Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model[2].
Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis[4].
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