Quisinostat
CAS No. : 875320-29-9
(Synonyms: JNJ-26481585)
| Size | Price | Stock |
|---|---|---|
| 5mg | $158 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $395 | In-stock |
| 50mg | $554 | In-stock |
| 100mg | $770 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15433 |
| M.Wt: | 394.47 |
| Formula: | C21H26N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 60°C) |
Quisinostat (JNJ-26481585) is a potent and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity[1]. Quisinostat can induce autophagy in neuroblastoma cells[2].
IC50 & Target:IC50: 0.11 nM (HDAC1), 0.33 nM (HDAC2), 0.64 nM (HDAC4), 0.46 nM (HDAC10), 0.37 nM (HDAC11)[1]
In Vitro:Quisinostat inhibits HDAC isozymes in vitro[1].
Quisinostat (30-1000 nM; 24 hours) is a potent pan-HDAC inhibitor in tumor cells[1].
Quisinostat has a broad spectrum antiproliferative activity against solid and hematologic cancer cell lines and induces apoptosis[1].
In Vivo:Quisinostat (40 mg/kg; p.o.; once daily; for 3 days) acts as a potent HDAC1 inhibitor that inhibits p21waf1,cip1 ZsGreen tumors in vivo[1].
Quisinostat induces continuous H3 acetylation in tumor tissue in vivo[1].
Quisinostat (10 mg/kg; once daily; i.p.; for 14 days) strongly inhibits the growth of large pre-established HCT116 colon xenografts[1].
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