Disoxaril
CAS No. : 87495-31-6
(Synonyms: WIN-51711)
| Size | Price | Stock |
|---|---|---|
| 5mg | $277 | In-stock |
| 10mg | $443 | In-stock |
| 25mg | $887 | In-stock |
| 50mg | $1420 | In-stock |
| 100mg | $2300 | In-stock |
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| Cat. No. : | HY-111233 |
| M.Wt: | 342.43 |
| Formula: | C20H26N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C) |
Disoxaril (WIN-51711) is an antivirus agent with activity against poliovirus types 1 and 2. Disoxaril inserts into the hydrophobic interior of virus capsid protein VP1 to stabilize virion conformation, inhibits poliovirus uncoating, and prevents viral RNA release and synthesis. Disoxaril can be used for the research of poliovirus infection[1][2].
In Vitro:Disoxaril (35-140 μM; 48 h) inhibits FL cell growth with a CGIC50 of 70 μM[1].
Disoxaril (0.03-0.3 μg/mL; 15 min preincubation) inhibits replication of poliovirus type 1 and type 2 in HeLa cells by stabilizing the virus capsid to block pH-dependent viral uncoating in endosomes and/or lysosomes[2].
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