S29434
CAS No. : 874484-20-5
(Synonyms: NMDPEF)
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $490 | In-stock |
| 50mg | $830 | In-stock |
| 100mg | $1400 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122614 |
| M.Wt: | 374.39 |
| Formula: | C21H18N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 19.29 mg/mL (ultrasonic) |
S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production[1]. IC50 & Target: IC50: 5 nM (h QR2, expressed in E. coli, NRH as co-substrate), 16 nM (h QR2, expressed in E. coli, with BNAH as co-substrate)[1] In Vitro: S29434 (5-10 μM; 24 h) induces HepG2 cells autophagy[1]. In Vivo: S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo[1].
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