Ned 19
CAS No. : 874374-25-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $260 | In-stock |
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| Cat. No. : | HY-103316A |
| M.Wt: | 514.59 |
| Formula: | C30H31FN4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM[1]. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice[2].
IC50 & Target: NAADP, Ca2+[1]
In Vitro: Ned 19 (25-100 μM; 24-72?hours) reduces cell proliferation[2].
Ned 19 (25-100 μM; 24-72?hours) reduces markedly the cell number[2].
Ned 19 (25-100 μM; 24-72?hours) reduces the S phase percentage and increases of the G0/G1 phase percentage evaluated by cell cycle analysis[2].
Ned 19 (25-100 μM; 24-72?hours) induces cell apoptosis a time-dependent manner[2].
Ned 19 (25-100 μM; 24-72?hours) reduces expression of N-cadherin and increases expression of E-cadherin, affecting the cell migratory behavior[2].
In Vivo: Ned 19 (i.p.; 5?mg/Kg/every second day; 4 week) impaires severely tumor growth[2].
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