JUN-1111
CAS No. : 874351-38-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $245 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $800 | In-stock |
| 50mg | $1280 | In-stock |
| 100mg | $2100 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-118529 |
| M.Wt: | 287.31 |
| Formula: | C15H17N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;heat to 80°C) |
JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1[1][2].
IC50 & Target:IC50:0.38 µM (Cdc25A); 1.8 µM (Cdc25B); 0.66 µM (Cdc25C); 28 µM (VHR); 37 µM (PTP1B)[1]
In Vitro:JUN-1111 (10, 30 µM; 17 h) induces cell cycle arrest at G1 and G2/M phase in tsFT210 cells[1].
JUN-1111 (10, 30 µM; 1 h) decreases the expression of phosphoCdk1 in a dose-dependent manner in tsFT210 cells[1].
JUN-1111 (0-20 µM) induces the formation of reactive oxygen species in mammalian cells[2].
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