T-2307
CAS No. : 873546-31-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $680 | In-stock |
| 25mg | $1350 | In-stock |
| 50mg | $2200 | In-stock |
| 100mg | $3400 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114220 |
| M.Wt: | 437.58 |
| Formula: | C25H35N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;adjust pH to 3 with HCl) |
T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including?Candida?species (MIC range, 0.00025 to 0.0078 μg/ml),?Cryptococcus neoformans?(MIC range, 0.0039 to 0.0625 μg/ml), and?Aspergillus?species (MIC range, 0.0156 to 4 μg/mL) [1].
In Vitro: T-2307 exhibits potent activity against fluconazole-resistant and fluconazole-susceptible-dose-dependent?Candida albicans?strains as well as against azole-susceptible strains[1].
T-2307 shows efficacy in a murine model of?candida glabrata?infection despite?in vitro?trailing growth phenomena[2].
In Vivo: In mouse models of disseminated candidiasis, cryptococcosis, and aspergillosis, the ED50 of T-2307 were 0.00755, 0.117, and 0.391 mg/kg, respectively[1].
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