Amtolmetin guacil
CAS No. : 87344-06-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $40 | In-stock |
| 25mg | $85 | In-stock |
| 50mg | $140 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-107320 |
| M.Wt: | 420.46 |
| Formula: | C24H24N2O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis[1][2]. IC50 & Target:Prostaglandin receptor, COX, NO[1][2] In Vitro:Amtolmetin guacil (100 μM; 0-60 min) converts to TMT (Tolmetin, HY-B1799) along with MED5 (1-methyl-5-p-methylbenzoyl-pyrrol-2-acetamido aceticacid) in rat fresh plasma and rat liver microsomal, rapidly converts to MED5 and MED5 methyl ester without yielding TMT in human fresh plasma and human liver microsomes[3].
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